The FTSE 100 is expected to fall by around 10 points on Wednesday, according to the spread betting firms, following mixed performances on US and Asian markets overnight.
In Asia, financials and manufacturers were generally lower. Soft China demand data, along with volatile commodity prices, did little to inspire much confidence among investors.
In the US, focus shifted back to corporate earnings rather than politics after the government shutdown came to an end on Monday.
Traders in London will be looking to the latest unemployment data in addition to a number of trading updates.
In the US overnight, the Dow closed 3.79 points lower at 26,210.81, the S&P 500 added 6.16 points to 2,839.13 and the NASDAQ gained 52.26 points at 7,460.29.
In Asia, the Nikkei was 157.99 points lower at 23,966.16 heading into the close.
The Hang Seng was little changed at 32,931.43.
Meanwhile, the Shanghai Composite was up 15.61 points, or 0.44%, at 3,562.12.
At 6:05am, WTI crude was 0.03% lower at $64.45 per barrel and Brent was down 0.20% at $69.82 per barrel.
Gold was 0.28% stronger at $1,340.40 per ounce, silver was up 0.72% and copper by 0.84%.
Trading Statements: Antofagasta, Empresaria, JD Wetherspoon, Polymetal, Sage and WH Smith.
Final Results: Crest Nicholson and Staffline.
AGM's / EGM's: Edinburgh Worldwide Investment Trust, Henderson Alternative Strategies Trust, McCarthy Stone and Troy Income & Growth Trust.
Economic News: Unemployment rate, claimant count and average earnings data.