The FTSE is set to start today's session in negative territory, according to the spread betting firms, as trader's attempt to second guess the next inflection point.
The FTSE 100 is called around 47 points lower on open.
Analysts appear to be concerned about geopolitical issues, bond yields and the ongoing volatility in commodity prices, which is also affecting sentiment across several continents.
A mix of Trump Tweets, Davos forum speeches, a stronger dollar and mediocre economic and Corporate data has also done little to inspire further confidence for investors in London.
Technology stocks, including Apple, are also coming under scrutiny as the fourth quarter earnings season unravels.
In the US overnight, the Dow ended 177.23 points lower at 26,439.48, the S&P 500 lost 19.34 points to close at 2,853.53 and NASDAQ finished the session 39.27 points weaker at 7,466.51.
The downturn in the US extended to Asia this morning, with the Nikkei 225 down 356.63 points at 23,272.71 heading into the close.
The Hang Seng was 335.71 points lower at 32,631.18 and the Shanghai Composite was 24.89 points lower at 3,498.11.
Closer to home, trading updates are due from miner Avocet, banking group CYBG, and pizza maker Domino's, among others.
At 6:10am, WTI crude was 1.08% lower at $64.85 per barrel but Brent was down 0.76% at $68.93 per barrel.
Gold was 0.52% weaker at $1,338.10 per ounce and silver was off by 0.27% and copper by 0.86%.
Trading Statements: Avocet Mining, CYBG, Domino's Pizza and UDG Healthcare.
Final Results: Oxford Biodynamics.
Interim Results: Filtronic, NWF and PZ Cussons.
AGM's / EGM's: Hollywood Bowl, Patisserie, Greencore, SolGold, Servoca, UDG Healthcare, Utilitywise and Zoopla.