The FTSE 100 is called around 17 points lower by financial spread betting firms following declines on Wall Street and markets in Asia.
Implications surrounding Brexit negotiations are also continuing to have a negative impact on sentiment in the City as Prime Minister Theresa May heads to China in an attempt to build further trade relations.
Focus in the US is currently on President Trump's maiden State of the Union speech, Fed chair Yellen's departure and today's interest rate decision.
The Dow ended yesterday's session 362.59 points lower at 26,076.89, the S&P 500 lost 31.10 points to close at 2,822.43 and NASDAQ finished 64.02 points softer at 7,402.48.
In Asia this morning, the Nikkei 225 was 111.72 points lower at 23,180.25 heading into the close.
The Hang Seng was up 44.38 points at 32,631.18 but the Shanghai Composite was 18.86 points lower at 3,469.15.
At around 6:20am, WTI crude was 0.87% lower at $63.94 per barrel and Brent was down 0.72% at $68.52 per barrel.
Gold was 0.47% higher at $1,346.30 per ounce, silver was up 0.69% and copper rose by 0.36%.
Trading Statements: Britvic, Dairy Crest, PPHE and SSE.
Final Results: Centamin and Low & Bonar.
Interim Results: Angle, Best Of The Best, Joules and Wizz Air.
AGM's / EGM's: Bilby, BMR, Britvic, CYBG, Finsbury Growth & Income Trust, Hon Hai Precision Industry, Infrastrata, Renew, Schroder UK Mid & Small Cap Fund, Sunrise Resources, Topps Tiles and Tertiary Minerals.
Economic Releases: The latest BRC Shop Price Index reading and data regarding consumer confidence.