Source - LSE Regulatory
RNS Number : 8621S
Redx Pharma plc
09 November 2023


("Redx" or the "Company")

Holdings in Company

Alderley Park, UK, 9 November 2023 Redx (AIM:REDX), the clinical-stage biotechnology company focused on discovering and developing novel, small molecule, targeted therapeutics for the treatment of fibrotic disease and cancer,  announces the following changes to its significant shareholders (being shareholders holding 3% or more of the Company's ordinary shares) pursuant to AIM Rule 17, following admission of the Subscription Shares to trading on AIM (as announced on 7 November 2023) and as detailed further in the circular to shareholders dated 18 October 2023.



Number of ordinary shares

Percentage of issued share capital

Funds managed by Redmile Group LLC



Sofinnova Crossover I SLP



Polar Capital LLP



Invus Public Equities L.P.




For further information, please contact:




Redx Pharma plc 

Caitlin Pearson, Head of Communications 

UK Headquarters

Lisa Anson, Chief Executive Officer

T: +44 (0)1625 469 918

US Office

Peter Collum, Chief Financial Officer


SPARK Advisory Partners (Nominated Adviser)

T: +44 (0)203 368 3550

Matt Davis/ Adam Dawes


WG Partners LLP (Joint Broker)


T: +44 (0)203 705 9330

Claes Spång/ Satheesh Nadarajah/ David Wilson


Panmure Gordon (UK) Limited (Joint Broker)


T: +44 (0)207 886 2500

Rupert Dearden/ Freddy Crossley/ Emma Earl



FTI Consulting

T: +44 (0)203 727 1000

Simon Conway/ Ciara Martin



About Redx Pharma Plc

Redx Pharma (AIM: REDX) is a clinical-stage biotechnology company focused on the discovery and development of novel, small molecule, targeted therapeutics for the treatment of fibrotic disease, cancer and the emerging area of cancer-associated fibrosis, aiming initially to progress them to clinical proof of concept before evaluating options for further development and potential value creation. The Company's lead fibrosis product candidate, the selective ROCK2 inhibitor, zelasudil (RXC007), is in development for interstitial lung disease and is undergoing a Phase 2a trial for idiopathic pulmonary fibrosis (IPF) with topline data expected in H1 2024. The Company's second fibrosis candidate, RXC008, a GI-targeted ROCK inhibitor for the treatment of fibrostenotic Crohn's disease, is progressing towards a CTA application during the fourth quarter of 2023.  Redx's lead oncology product candidate, the Porcupine inhibitor RXC004, being developed as a targeted treatment for Wnt-ligand dependent cancers, is expected to report anti-PD-1 combination Phase 2 data during the first half of 2024, following which Redx will seek a partner for ongoing development.   In October 2023, Redx nominated its next development candidate, RXC009 a highly potent and selective DDR1 inhibitor for the treatment of chronic kidney disease and associated fibrosis.

The Company has a strong track record of discovering new drug candidates through its core strengths in medicinal chemistry and translational science, enabling the Company to discover and develop differentiated therapeutics against biologically or clinically validated targets. The Company's accomplishments are evidenced not only by its wholly-owned clinical-stage product candidates and discovery pipeline, but also by its strategic transactions, including the sale of pirtobrutinib (RXC005, LOXO-305), a non-covalent (reversible) BTK inhibitor now approved by the US FDA for adult patients with mantle cell lymphoma previously treated with a covalent BTK inhibitor, and AZD5055/RXC006, a Porcupine inhibitor targeting fibrotic diseases including IPF, which AstraZeneca is progressing in a Phase 1 clinical study. In addition, Redx has forged collaborations with Jazz Pharmaceuticals, which includes JZP815, a pan-RAF inhibitor developed by Redx which Jazz is now progressing through Phase 1 clinical studies, and an early stage oncology research collaboration.  



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