14 June 2023

Aptamer Group plc

("Aptamer", or " the Group")

Aptamer Group and Neuro-Bio partner to develop an Alzheimer's disease diagnostic test

-       Optimer binders have been successfully developed to a novel Alzheimer's disease biomarker

-       Aptamer Group CTO, Dr David Bunka, will present at Neuro-Bio's Science Day on Optimer technology and the development of binders to support the diagnostic

Aptamer Group plc (AIM: APTA), the developer of novel Optimer^® binders to enable innovation in the life sciences industry, and Neuro-Bio, an Oxford-based biotechnology company with a therapeutic focus on neurodegenerative disease, announce success in the development of Optimer binders to enable a lateral flow test for the early diagnosis of Alzheimer's disease.

Aptamer Group has successfully developed a panel of Optimer binders to a novel Alzheimer's disease biomarker. The Optimer binders have been patented by partners at Neuro-Bio, following the demonstration of performance in specifically binding to the target biomarker and functionality in a nasal mucous matrix. Further integration of the binders into a routine lateral flow test will support the clinical and commercial development of rapid diagnostics for Alzheimer's disease via simple nasal sampling, with the potential to diagnose the disease as early as 10-20 years before symptoms emerge.

The novel Alzheimer's disease biomarker, a peptide 'T14'was discovered and is currently being further validated by Neuro-Bio, led by the eminent neuroscientist Baroness Susan Greenfield. Early detection of Alzheimer's disease is critical to allow interventions that could prevent the onset of devastating memory loss and confusion in these patients. Neuro-Bio is working in parallel to develop a complementary therapy that could stabilise disease progression in diagnosed patients, ideally at the presymptomatic stage.

Dr David Bunka, Chief Technical Officer of Aptamer Group, will take part in Neuro-Bio's Science Day today at the Royal College of Physicians, discussing the development of the Optimer binders in partnership with Neuro-Bio, and the potential for diagnostic development.

Dr Rob Quinn, Interim Chief Executive Officer of Aptamer Group, commented: "We are pleased to be able to support the team at Neuro-Bio with the development of Optimer binders to enable their revolutionary diagnostic for Alzheimer's disease. Optimer binders have proven performance in lateral flow test formats and our success in delivering functional Optimer binders to Neuro-Bio's biomarker facilitates further diagnostic development. With an increasingly aging population and no current tests available for early-stage diagnosis, the advancement of new biomarkers and diagnostics in this field offers hope to the millions of patients and their loved ones worldwide."

Baroness Susan Greenfield, CEO of Neuro-Bio, commented: 'We're delighted to be working with Aptamer Group on this potentially game-changing technology to combat one of the biggest unmet medical needs of our time. It's a further example of UK ingenuity and teamwork for highly innovative and disruptive science.' 

- ENDS -

For further information, please contact:

Aptamer Group plc

Dr Rob Quinn                                                                                           +44 (0) 1904 217 404

SPARK Advisory Partners Limited - Nominated Adviser  

Andrew Emmott / Adam Dawes                                                          +44 (0) 20 3368 3550

Liberum Capital Limited - Broker

Richard Lindley / Ben Cryer / Cara Murphy                                         +44 (0) 20 3100 2000

Consilium Strategic Communications

Matthew Neal / Chris Welsh / Lucy Featherstone                             +44 (0) 20 3709 5700

aptamergroup@consilium-comms.com

About Aptamer Group plc

Aptamer Group develops custom affinity binders through its proprietary Optimer^® platform to enable new approaches in therapeutics, diagnostics, and research applications. The Company strives to deliver transformational solutions that meet the needs of life science researchers and developers through the use of its proprietary Optimer platform.

Optimer binders are oligonucleotide affinity ligands that can function as an antibody alternative. The global affinity ligand market is currently worth over $170 billion. Optimer binders are engineered to address many of the issues found with alternative affinity molecules, such as antibodies, and offer new, innovative solutions to bioprocessing, diagnostic and pharmaceutical scientists.

Aptamer Group has successfully delivered projects for global pharma companies, diagnostic development companies, and research institutes covering a range of targets and applications with the objective of establishing royalty-bearing licenses. Through the unique Optimer technology and processes, scientists and collaborators can make faster, more informed decisions that support discovery and development across the Life Sciences.