Renalytix plc

("Renalytix" or the "Company")

Issue of Shares

LONDON and SALT LAKE CITY - October 17, 2023 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), announces the repayment of $1.06 million of the Company's convertible bond, further details of which were announced on 31 March 2022. The repayment is being made through the issue of 150,000 Ordinary Shares and 1,092,694 American Depositary Shares ("ADS").

After settlement of the repayment, the principal remaining under the convertible bond will be reduced by $1.06 million to $14.84 million.

2,335,388 new ordinary shares of £0.0025 each in the capital of the Company (the "Ordinary Shares") will be issued to settle including the conversion of 1,092,694 ADSs (2,185,388 Ordinary Shares with each ADS representing two Ordinary Shares).

An application has been made to the London Stock Exchange for the new Ordinary Shares to be admitted to trading on AIM. It is expected that admission of the 2,335,388 new Ordinary Shares to trading on AIM will become effective on, or around, 8am UK time on 19 October 2023 ("Admission"). The new Ordinary Shares will rank pari passu with the existing Ordinary Shares of the Company.

Total voting rights

Following Admission, the Company will have 97,430,156 Ordinary Shares in issue with each share carrying the right to one vote. The Company has no Ordinary Shares held in treasury. The total number of voting rights in the Company following Admission will therefore be 97,430,156.

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About Renalytix

Renalytix (NASDAQ: RNLX) (LSE: RENX) is an in-vitro diagnostics and laboratory services company that is the global founder and leader in the new field of bioprognosis™for kidney health. The leadership team, with a combined 200+ years of healthcare and in-vitro diagnostic experience, has designed its KidneyIntelX laboratory developed test to enable risk assessment for rapid progressive decline in kidney function in adult patients with T2D and early CKD (stages 1-3). We believe that by understanding how disease will progress, patients and providers can take action early to improve outcomes and reduce overall health system costs. For more information, visit www.renalytix.com.